Saturday, 13 Apr 2024


As a result of extreme adverse effects, several notable safety issues, as well as diet plan restrictions, numerous doctors opt to treat people with more secure SNRIs and SSRIs prior to attempting an MAOI drug. The most typical negative effects discovered with MAOIs include the following:

  • Cottonmouth
  • Sleeplessness
  • Headaches
  • Drowsiness
  • Lightheadedness
  • Digestive system concerns
  • Skin irritation if taken as a spot


Although these are not hazardous negative effects, they can lower an individual’s lifestyle. Nonetheless, there are a couple of hazardous as well as potentially extreme negative effects associated with MAOIs:

  • Muscle mass spasms
  • Low blood pressure
  • Lowered sex drive as well as lack of ability to get to orgasm
  • Difficulty urinating
  • Paresthesia
  • Muscle mass aches

Also, MAOIs can react alarmingly to specific foods. MAOIs engage poorly with a compound called tyramine, which is found in some red wines, aged cheeses, fermented foods, draft beers, treated meats, as well as soy items. It can cause dangerously high as well as potentially fatal blood pressure.

MAOIs are likewise not secure for pregnancy as well as can communicate improperly with allergy, as well as cold medications. Some individuals may likewise have an adverse reaction to MAOIs called Serotonin Disorder, where individuals experience stress and depression, anxiety, and fast heart rate.

Serotonin disorder is more likely to happen when people combine MAOI medicines with various other antidepressants, such as SSRIs. 

Consequently, it is essential to wait two weeks prior to starting an MAOI after you terminate utilizing one more antidepressant medication to permit the old drug to clear from your system, so it does not interact with the MAOI.

Serotonin disorder is possibly deadly and can entail the following serious signs and symptoms:

  • Fever
  • Extreme Sweating
  • Complication
  • Seizures
  • Inflexible muscles
  • Liver as well as Kidney Problems

Provided the potential side effects of MAOIs, customers must exercise care with these medicines, as well as interact with their medical professionals regarding any side effects and any type of other medicines they are taking.

While it is not usual for high tyramine levels to create severe side effects, a tyramine buildup can bring about high blood pressure levels in uncommon cases. In uncommon circumstances, an individual might experience a fatal cerebral hemorrhage. Provided the possibly hazardous adverse effects of MAOI medications, individuals that take these medications for clinical depression must follow limiting diet regimens. For instance, as professionals caution, tyramine levels enhance as foods age, so even leftovers can become bothersome when taking an MAOI prescription. When fruits like avocados or bananas become as well ripe, they can additionally come to be harmful. Some individuals might find these dietary constraints related to MAOIs challenging to handle.